Meningeal involvement in apparently ANCA-negative Wegener's granulomatosis: a role for PR3 capture-ELISA?
نویسندگان
چکیده
منابع مشابه
Meningeal involvement in apparently ANCA-negative Wegener's granulomatosis: a role for PR3 capture-ELISA?
SIR, Central nervous system (CNS) involvement is rare in Wegener's granulomatosis (WG): the spectrum of CNS manifestations includes cerebrovascular events, seizures and cranial nerve abnormalities [1, 2]. Meningitis is exceedingly rare, and its diagnosis often challenging [1–3]. A 57-yr-old man was admitted to hospital because of untreatable headache, photophobia, neck stiffness and paranasal s...
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ment [4–6]. This prevalence is high if we consider that only 5–10% of WG patients were shown to have CNS disease in large cohorts [6]. Therefore, ANCA-negative WG may hide remarkable CNS involvement [5]. In our patient, WG initially presented as a systemic disease and C-ANCA (anti-PR3) tested positive using routine IIF and direct-ELISA. At the time WG relapsed with upper airway tract and mening...
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ژورنال
عنوان ژورنال: Rheumatology
سال: 2007
ISSN: 1462-0324,1462-0332
DOI: 10.1093/rheumatology/kem094